differentiation antigens การใช้

• Tissue differentiation antigens are those that are specific to a certain type of tissue.
• CD48 was the first B-cell-specific cellular differentiation antigen identified in transformed B lymphoblasts.
• The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor.
• Touloukian " et al . " have characterized OA1 immunologically as a melanoma / melanocyte differentiation antigen.
• Melanocytic differentiation antigen gp100 has also been used as a vaccine and extended survival has been observed in the group of vaccinated patients.
• Other examples include tissue differentiation antigens, mutant protein antigens, oncogenic viral antigens, cancer-testis antigens and vascular or stromal specific antigens.
• Unexpectedly, spontaneous T cell responses to differentiation antigens have been well documented in melanoma patients, with T cells recognizing tumour cells and normal melanocytes.
• Wang, CY, Azzo W, Al-Katib A, Chiorazzi N and Knowles DM . Preparation and characterization of monoclonal antibodies recognizing three distinct differentiation antigens ( BL1, BL2, and BL3 ) on human B lymphocytes.
• Complete remissions have been observed in leukemic patients infused with T cells genetically engineered to carry an artificial receptor that recognizes CD19, a differentiation antigen present at the surface of normal B lymphocytes and of B cell leukemias and lymphomas.
• It was originally named theta ( ? ) antigen, then Thy-1 ( "'THYmocyte differentiation antigen 1 "') due to its prior identification in thymocytes ( precursors of T cells in the thymus ).
• Peng RL, Al-Katib A, Knowles DM, Lu L, Broxmeyer H, Telidjian B, C Hiao JW and Wang, CY . Preparation and characterization of monoclonal antibodies recognizing two distinct differentiation antigens Pro-Im1, Pro-Im2 on early hematopoeitic cells.
• In earlier work, he and his colleagues introduced Bacillus Calmette-Gu閞in ( BCG ) to tumor immunotherapy; discovered the first link between the major histocompatibility complex ( MHC ) and disease ( leukemia ); found the unexpected association between Epstein-Barr virus ( EBV ) and nasopharyngeal carcinoma; discovered Tumor necrosis factors ( TNF ); defined the concept of cell-surface differentiation antigens with the discovery of TL, Lyt ( CD8 ), and a range of other mouse antigenic systems; discovered p53, independently with two other groups; and identified the tumor immunogenicity of heat shock proteins.